Coagulation factor IX Recombinant Protein

F9/Coagulation factor IX/Christmas factor/Plasma thromboplastin component/PTC/Coagulation factor IXa light chain/Coagulation factor IXa heavy chain, F9

This recombinant protein can be used for biological assays. For research use only.

Coagulation factor IX (F9), is a member of the peptidase S1 family. It contains two EGF-like domains, a Gla domain and a peptidase S1 domain. It is primarily expressed in the liver and secreted in plasma. Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca2+ ions, phospholipids, and factor VIIIa. Mutations in position 43 and 46 prevents cleavage of the propeptide, mutation in position 93 probably fails to bind to cell membranes, mutation in position 191 or in position 226 prevent cleavage of the activation peptide. Mutations of human F9 can result in thrombophilia and recessive X-linked hemophilia B (HEMB). An X-linked blood coagulation disorder characterized by a permanent tendency to hemorrhage, due to factor IX deficiency. It is phenotypically similar to hemophilia A, but patients present with fewer symptoms. Many patients are asymptomatic until the hemostatic system is stressed by surgery or trauma.

Supplied as a 0.2 um filtered solution of 20mM TrisHCl,150mM NaCl,10% Glycerol,pH8.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

C-6 His tag

2158

coagulation factor IX

F9

Homo sapiens

Liquid

49.8 kD

P00740

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

Thr32-Gly402

Human Cells

P00740