ProSci

CD40L multimeric Recombinant Protein

Product Code:
 
PSI-90-289
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Storage:
 
Stable for at least 6 months after receipt when stored at -20˚C.
 

No additional charges, what you see is what you pay! *

CodeSizePrice
PSI-90-289-10ug10ug£626.00
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 14-21 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • Show All

Further Information

Additional Names:
ACRP30headless:CD40L, ACRP30headless:CD154, ACRP30headless:TNFSF5, ADIPOQ-CD40L
Application Note:
This recombinant proteins is for research use only.
Background:
MultimericCD40L™ is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to CD40L+enhancer combinations. MultimericCD40L™ has been shown to suppress alum-induced IL-1beta release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM (Bone marrow-derived macrophages) viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced.
Biological Activity:
Induces B cell activation (as demonstrated by dose-dependent upregulation of CD86).
Buffer:
Contains PBS. Reconstitute with 100 μl sterile water.
Concentration:
0.1mg/ml after reconstitution.
Fusion Tag:
DDDDK Tag
NCBI Gene ID #:
84349
NCBI Official Name:
Cd40lg
NCBI Official Symbol:
CD40 ligand
NCBI Organism:
Rattus norvegicus
Physical State:
Lyophilized
Protein Accession #:
Q9Z2V2
Protein GI Number:
21362974
Purity:
>95% (SDS-PAGE).

Endotoxin level is less than 0.02EU/ μg purified protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
CHO cells
Swissprot #:
Q8WWZ1

Documents