ProSci

Clusterin nuclear form Recombinant Protein

Product Code:
 
PSI-90-051
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Storage:
 
Working aliquots are stable for up to 3 months when stored at -20˚C.
 

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PSI-90-051-50ug50ug£657.00
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Further Information

Additional Names:
TRPM-2, Apolipoprotein J, APO-J, CLI, CLU, SGP-2
Application Note:
This recombinant proteins is for research use only.
Background:
Clusterin shares homology with the small heat shock protein family of molecular chaperones. The mature secreted form of the protein is a glycosylated, 80-kDa disulfide-linked heterodimer of alpha and beta subunits (produced by internal cleavage). Clusterin is expressed in virtually all tissues and found in all human fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling, and immune system regulation. Clusterin also exists as a nuclear protein. The secreted form of Clusterin has extracellular chaperone and anti-apoptotic activities while the nuclear form acts as a proapoptotic factor.
Buffer:
0.2um-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl.
Concentration:
1mg/ml
Fusion Tag:
His Tag
NCBI Gene ID #:
12759
NCBI Official Name:
clusterin
NCBI Official Symbol:
Clu
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
Q549A5
Protein GI Number:
81887962
Purity:
>90% (SDS-PAGE).

Endotoxin level is less than 1EU/ μg purified protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
P10909

Documents