ProSci

HO-1 Recombinant Protein

Product Code:
 
PSI-91-128
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
Store at -20˚C, stable for 6 months after receipt.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
 

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CodeSizePrice
PSI-91-128-0.05mg0.05mg£673.00
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Further Information

Additional Names:
Heme Oxygenase 1, HO-1, HMOX1, HO, HO1, HSP32
Application Note:
This recombinant protein can be used for biological assays. For research use only.
Background:
Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HO-1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. HO-1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA. HO-1 is involved in the regulation of cardiovascular function and response to a variety of stressors. Defects in HO-1 are the cause of Heme Oxygenase 1 deficiency, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues.
Buffer:
Supplied as a 0.2 um filtered solution of 20mM PB, 150mM NaCl, 1mM EDTA, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Fusion Tag:
Tag Free
NCBI Gene ID #:
3162
NCBI Official Name:
heme oxygenase 1
NCBI Official Symbol:
HMOX1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Predicted Molecular Weight:
29.86 kD
Protein Accession #:
P09601
Purity:
Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
P09601

Documents