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Switzerland.
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Further Information
Alternate Names/Synonyms:
AMG706
Solid.
453562-69-1
32160000
liquid
GHS07
H303, H317, H333
InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28)
RAHBGWKEPAQNFF-UHFFFAOYSA-N
Chemical. CAS: 453562-69-1. Formula: C22H23N5O. MW: 373.5. Motesanib (AMG 706) is a multi-targeted anti-cancer agent with an inhibitory action on human vascular endothelial growth factor receptors 1, 2 and 3 (VEGFR1-3) with IC(50) values of 2nM, 3nM and 6nM. It also inhibits platelet-derived growth factor receptor (PDGFR) and cellular stem-cell factor receptor (c-KIT).
C22H23N5O
373.5
Plastic Vial
P261, P272, P280, P302, P352, P333, P313, P321, P363, P501
Motesanib (AMG 706) is a multi-targeted anti-cancer agent with an inhibitory action on human vascular endothelial growth factor receptors 1, 2 and 3 (VEGFR1-3) with IC(50) values of 2nM, 3nM and 6nM. It also inhibits platelet-derived growth factor receptor (PDGFR) and cellular stem-cell factor receptor (c-KIT).
>95%
Warning
Soluble in DMSO or ethanol.
Non-hazardous
Protein Kinase Modulators
12352200
Stable for at least 2 years after receipt when stored at -20°C.