AdipoGen Life Sciences

CP-724714

Product Code:
 
SYN-1033
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
-20°C
1 / 1
Chemical Structure
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Chemical Structure

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Further Information

Alternate Names/Synonyms:
CP724714
Appearance:
Solid.
CAS:
383432-38-0
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C27H27N5O3/c1-18-13-21(8-11-25(18)35-22-9-6-19(2)29-15-22)32-27-23-14-20(7-10-24(23)30-17-31-27)5-4-12-28-26(33)16-34-3/h4-11,13-15,17H,12,16H2,1-3H3,(H,28,33)(H,30,31,32)/b5-4+
InChiKey:
LLVZBTWPGQVVLW-SNAWJCMRSA-N
Long Description:
Chemical. CAS: 383432-38-0. Formula: C27H27N5O3. MW: 469.5. CP-724714 is an oral, selective and potent ErbB-2 (HER2) kinase inhibitor with an IC(50) of 10 nM. It has >640-fold selectivity for ErbB-2 (HER2) over EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met.
Molecular Formula:
C27H27N5O3
Molecular Weight:
469.5
Package Type:
Plastic Vial
Product Description:
CP-724714 is an oral, selective and potent ErbB-2 (HER2) kinase inhibitor with an IC(50) of 10 nM. It has >640-fold selectivity for ErbB-2 (HER2) over EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor: J.P. Jani, et al.; Cancer Res. 67, 9887 (2007)