Further Information
Alternate Names/Synonyms:
BID1870
Solid.
501437-28-1
32160000
liquid
GHS07
H303, H317, H333
InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24)
DTEKTGDVSARYDS-UHFFFAOYSA-N
Chemical. CAS: 501437-28-1. Formula: C19H23F2N5O2. MW: 391.4. BI-D1870 is a small molecule, specific inhibitor of p90 RSK (ribosomal S6 kinase) isoforms RSK1, RSK2, RSK3 and RSK4, both in vitro and in vivo, with IC(50)s are 31nM, 24nM, 18nM, 15nM, respectively. It shows a 10- to 100-fold selectivity for RSK over MST2, GSK-3beta, MARK3, CK1 and Aurora B.
C19H23F2N5O2
391.4
Plastic Vial
P280, P301, P312, P304, P312, P302, P352, P333, P313
BI-D1870 is a small molecule, specific inhibitor of p90 RSK (ribosomal S6 kinase) isoforms RSK1, RSK2, RSK3 and RSK4, both in vitro and in vivo, with IC(50)s are 31nM, 24nM, 18nM, 15nM, respectively. It shows a 10- to 100-fold selectivity for RSK over MST2, GSK-3beta, MARK3, CK1 and Aurora B.
>95%
Warning
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Non-hazardous
Protein Kinase Modulators
12352200
Stable for at least 2 years after receipt when stored at -20°C.