AdipoGen Life Sciences

YM201636 hydrochloride

Product Code:
 
SYN-1094
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
-20°C
1 / 1
Chemical Structure
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Chemical Structure

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Further Information

Alternate Names/Synonyms:
YM-201636
Appearance:
Solid.
CAS:
371942-69-7 (free base)
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C25H21N7O3.ClH/c26-19-7-6-16(14-28-19)24(33)29-17-4-1-3-15(13-17)22-30-20-18-5-2-8-27-25(18)35-21(20)23(31-22)32-9-11-34-12-10-32;/h1-8,13-14H,9-12H2,(H2,26,28)(H,29,33);1H
InChiKey:
FZSHKSKFIDALKO-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 371942-69-7 (free base). Formula: C25H21N7O3 . HCl. MW: 467.4 . 36.5. YM-201636 is a cell-permeable and selective inhibitor of PIKfyve (IC(50) of 33nM). It disrupts retroviral budding from cells, apparently by interfering with the endosomal sorting complex required for transport (ESCRT) machinery. In adipocytes, YM-201636 also inhibits basal and insulin-activated 2-deoxyglucose uptake (IC(50) of 54nM).
Molecular Formula:
C25H21N7O3 . HCl
Molecular Weight:
467.4 . 36.5
Package Type:
Plastic Vial
Product Description:
YM-201636 is a cell-permeable and selective inhibitor of PIKfyve (IC(50) of 33nM). It disrupts retroviral budding from cells, apparently by interfering with the endosomal sorting complex required for transport (ESCRT) machinery. In adipocytes, YM-201636 also inhibits basal and insulin-activated 2-deoxyglucose uptake (IC(50) of 54nM).
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding: H.B. Jefferies, et al.; EMBO Rep. 9, 164 (2008)