AdipoGen Life Sciences

GCI1746

Product Code:
 
SYN-1164
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
-20°C
1 / 1
Chemical Structure
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Chemical Structure

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Further Information

Alternate Names/Synonyms:
GCI-1746; G-182
Appearance:
Solid.
CAS:
910232-84-7
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C34H37N5O4/c1-22-27(7-6-8-28(22)37-31(40)23-9-13-25(14-10-23)34(2,3)4)29-21-38(5)33(42)30(36-29)35-26-15-11-24(12-16-26)32(41)39-17-19-43-20-18-39/h6-16,21H,17-20H2,1-5H3,(H,35,36)(H,37,40)
InChiKey:
JIFCFQDXHMUPGP-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 910232-84-7. Formula: C34H37N5O4. MW: 579.7. CGI1746 was identified as a selective and potent ATP-competitive BTK inhibitor with an IC(50) of 1.9nM. It is specific for BTK, with around 1000-fold selectivity over Tec and Src family kinases.
Molecular Formula:
C34H37N5O4
Molecular Weight:
579.7
Package Type:
Plastic Vial
Product Description:
CGI1746 was identified as a selective and potent ATP-competitive BTK inhibitor with an IC(50) of 1.9nM. It is specific for BTK, with around 1000-fold selectivity over Tec and Src family kinases.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis: J.A. Di Paolo, et al.; Nat. Chem. Biol. 7, 41 (2011)