AdipoGen Life Sciences

XL019

Product Code:
 
SYN-1191
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
4°C
1 / 1
Chemical Structure
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Chemical Structure

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Further Information

Alternate Names/Synonyms:
XL-019
Appearance:
Solid.
CAS:
945750-13-0
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C25H28N6O2/c32-24(23-2-1-12-26-23)28-19-5-3-18(4-6-19)22-11-13-27-25(30-22)29-20-7-9-21(10-8-20)31-14-16-33-17-15-31/h3-11,13,23,26H,1-2,12,14-17H2,(H,28,32)(H,27,29,30)/t23-/m1/s1
InChiKey:
ISOCDPQFIXDIMS-HSZRJFAPSA-N
Long Description:
Chemical. CAS: 945750-13-0. Formula: C25H28N6O2. MW: 444.5. XL019 is a potent JAK2 inhibitor (IC(50) of 2nM) with excellent selectivity versus the other members of the JAK kinase family (JAK1, IC(50) of 130nM; JAK3, IC(50) of 250nM; TYK2, IC(50) of 340nM).
Molecular Formula:
C25H28N6O2
Molecular Weight:
444.5
Package Type:
Plastic Vial
Product Description:
XL019 is a potent JAK2 inhibitor (IC(50) of 2nM) with excellent selectivity versus the other members of the JAK kinase family (JAK1, IC(50) of 130nM; JAK3, IC(50) of 250nM; TYK2, IC(50) of 340nM).
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at +4°C.

References

SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors: T. Forsyth, et al.; Bioorg. Med. Chem. Lett. 22, 7653 (2012)