AdipoGen Life Sciences

ER 172594-06 hydrobromide

Product Code:
 
SYN-3002
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
-20°C
1 / 1
Chemical Structure
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Chemical Structure

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SYN-3002-M0011 mg£238.00
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SYN-3002-M0055 mg£549.00
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SYN-3002-M01010 mg£848.00
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Further Information

Alternate Names/Synonyms:
Atopaxar hydrobromide; ER-172594-06; E5555
Appearance:
Solid.
CAS:
474550-69-1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Hazards:
H302, H317, H335
InChi:
InChI=1S/C29H38FN3O5.BrH/c1-7-37-23-15-19-16-33(28(31)24(19)25(30)27(23)38-8-2)17-22(34)18-13-20(29(3,4)5)26(35-6)21(14-18)32-9-11-36-12-10-32;/h13-15,31H,7-12,16-17H2,1-6H3;1H
InChiKey:
UNMBLVOFOAGGCG-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 474550-69-1. Formula: C29H39BrFN3O5 . HBr. MW: 608.5 . 80.9. E5555 shows potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC values of 0.064 and 0.031µM, respectively.
Molecular Formula:
C29H39BrFN3O5 . HBr
Molecular Weight:
608.5 . 80.9
Package Type:
Plastic Vial
Precautions:
P261, P264, P301, P312
Product Description:
E5555 shows potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC values of 0.064 and 0.031µM, respectively.
Purity:
>95%
Signal word:
Warning
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

The in-vitro effects of E5555, a protease-activated receptor (PAR)-1 antagonist, on platelet biomarkers in healthy volunteers and patients with coronary artery disease: V.L. Serebruany, et al.; Thromb. Haemost. 102, 111 (2009) | Double-blind, placebo-controlled Phase II studies of the protease-activated receptor 1 antagonist E5555 (atopaxar) in Japanese patients with acute coronary syndrome or high-risk coronary artery disease: S. Goto, et al.; Eur. Heart J. 31, 2601 (2010) | The novel and orally active thrombin receptor antagonist E5555 (Atopaxar) inhibits arterial thrombosis without affecting bleeding time in guinea pigs: M. Kogushi, et al.; Eur. J. Pharmacol. 657, 131 (2011)