Further Information
Phosphatidylinositol 3-kinase regulatory subunit beta, PI3-kinase regulatory subunit beta, PI3K regulatory subunit beta, PtdIns-3-kinase regulatory subunit beta, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta, PI3-kinase subunit p85-beta, PtdIns-3-kinase regulatory subunit p85-beta, PIK3R2
For WB starting dilution is: 1:1000
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. The family has been classified into 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
PIK3R2 binds to activated Protein Tyrosine Kinases, which are phosphorylated, through its SH2 domain, and acts as an adaptor, mediating the association of the P110 catalytic unit to the plasma membrane.
- Khan, N.A., et al., J. Neurovirol. 9(6):584-593 (2003).
- Deregibus, M.C., et al., J. Biol. Chem. 277(28):25195-25202 (2002).
- Cook, J.A., et al., J. Immunol. 169(1):254-260 (2002).
- Park, I.W., et al., Blood 97(2):352-358 (2001).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
This PIK3R2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 442-471 amino acids from human PIK3R2.
5296
Phosphatidylinositol 3-kinase regulatory subunit beta
PIK3R2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
82 kDa
O00459
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Cell Cycle,Immunology,Signal Transduction
O00459
Optimal dilutions for each application to be determined by the researcher.