Further Information
Matrix metalloproteinase-20, MMP-20, 3424-, Enamel metalloproteinase, Enamelysin, MMP20
For WB starting dilution is: 1:1000
Proteins of the matrix metalloproteinase (MMP) family are
involved in the breakdown of extracellular matrix in normal
physiological processes, such as embryonic development,
reproduction, and tissue remodeling, as well as in disease
processes, such as arthritis and metastasis. Most MMP's are
secreted as inactive proproteins which are activated when cleaved
by extracellular proteinases. The protein encoded by this gene
degrades amelogenin, the major protein component of dental enamel
matrix, and so the protein is thought to play a role in tooth
enamel formation. A mutation in this gene, which alters the normal
splice pattern and results in premature termination of the encoded
protein, has been associated with amelogenesis imperfecta. This
gene is part of a cluster of MMP genes that localizes to chromosome
11q22.3.
- Bailey, S.D., et al. Diabetes Care (2010) In press :
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Wojciechowski, R., et al. Invest. Ophthalmol. Vis. Sci. (2010) In press :
- Lee, S.K., et al. J. Dent. Res. 89(1):46-50(2010)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine
This MMP20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 399-428 amino acids from the C-terminal region of human MMP20.
9313
Matrix metalloproteinase-20
MMP20
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
54 kDa
O60882
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Cell Cycle,Signal Transduction
O60882
Optimal dilutions for each application to be determined by the researcher.