Further Information
Epithelial discoidin domain-containing receptor 1, Epithelial discoidin domain receptor 1, CD167 antigen-like family member A, Cell adhesion kinase, Discoidin receptor tyrosine kinase, HGK2, Mammary carcinoma kinase 10, MCK-10, Protein-tyrosine kinase 3A, Protein-tyrosine kinase RTK-6, TRK E, Tyrosine kinase DDR, Tyrosine-protein kinase CAK, CD167a, DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. MCK10 is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain.
- Vogel, W., et al., Mol. Cell 1(1):13-23 (1997).
- Playford, M.P., et al., Genome Res. 6(7):620-627 (1996).
- Perez, J.L., et al., Oncogene 12(7):1469-1477 (1996).
- Valent, A., et al., Hum. Genet. 98(1):12-15 (1996).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This MCK10 antibody is generated from rabbits immunized with recombinant human MCK10 protein.
780
Epithelial discoidin domain-containing receptor 1
DDR1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
101 kDa
Q08345
729008
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Cancer,Neuroscience
Q08345
Optimal dilutions for each application to be determined by the researcher.