Further Information
Type III iodothyronine deiodinase, 5DIII, DIOIII, Type 3 DI, Type-III 5'-deiodinase, DIO3, ITDI3, TXDI3
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
DIO3 belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
- Bessho, K., et al. Eur. J. Pediatr. 169(2):215-221(2010)
- Wallace, C., et al. Nat. Genet. 42(1):68-71(2010)
- Aerts, G., et al. Endocrinology 150(11):5171-5180(2009)
- Panicker, V., et al. J. Clin. Endocrinol. Metab. 94(5):1623-1629(2009)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This DIO3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-278 amino acids from the C-terminal region of human DIO3.
1735
Type III iodothyronine deiodinase
DIO3
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
34 kDa
P55073
172045679
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Obesity,Neuroscience,Signal Transduction
P55073
Optimal dilutions for each application to be determined by the researcher.