Antibody Isotype:
Rabbit Ig
Antibody Clonality:
Polyclonal
Application:
Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
No additional charges, what you see is what you pay! *
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available!
Contact us to find what you can save.
This product comes from:
United States.
Typical lead time:
14-21 working days.
Contact us for more accurate information.
- Further Information
- Documents
- Show All
Further Information
F-box only protein 11, Protein arginine N-methyltransferase 9, Vitiligo-associated protein 1, VIT-1, FBXO11, FBX11, PRMT9, VIT1
For WB starting dilution is: 1:1000
This gene encodes a member of the F-box protein family
which is characterized by an approximately 40 amino acid motif, the
F-box. The F-box proteins constitute one of the four subunits of
ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),
which function in phosphorylation-dependent ubiquitination. The
F-box proteins are divided into 3 classes: Fbws containing WD-40
domains, Fbls containing leucine-rich repeats, and Fbxs containing
either different protein-protein interaction modules or no
recognizable motifs. The protein encoded by this gene belongs to
the Fbxs class. It can function as an arginine methyltransferase
that symmetrically dimethylates arginine residues, and it acts as
an adaptor protein to mediate the neddylation of p53, which leads
to the suppression of p53 function. This gene is known to be
down-regulated in melanocytes from patients with vitiligo, a skin
disorder that results in depigmentation. Polymorphisms in this gene
are associated with chronic otitis media with effusion and
recurrent otitis media (COME/ROM), a hearing loss disorder, and the
knockout of the homologous mouse gene results in the deaf mouse
mutant Jeff (Jf), a single gene model of otitis media.
Alternatively spliced transcript variants encoding distinct
isoforms have been identified for this gene.
- Guan, C., et al. Int. J. Mol. Med. 26(1):57-65(2010)
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Guan, C.P., et al. Zhonghua Yi Xue Za Zhi 90(16):1126-1130(2010)
- Abida, W.M., et al. J. Biol. Chem. 282(3):1797-1804(2007)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This FBXO11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the N-terminal region of human FBXO11.
80204
F-box only protein 11
FBXO11
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
104 kDa
Q86XK2
124012093
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cell Cycle
Q86XK2
Optimal dilutions for each application to be determined by the researcher.