ProSci

SEPT2 Antibody

Product Code:
 
PSI-58-704
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
1 / 2
Western blot analysis in NCI-H460 cell line lysates (35ug/lane).
2 / 2
Western blot analysis of SEPT2 using rabbit polyclonal SEPT2 Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SEPT2 gene.
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Western blot analysis in NCI-H460 cell line lysates (35ug/lane).
Western blot analysis of SEPT2 using rabbit polyclonal SEPT2 Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SEPT2 gene.

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PSI-58-704-400ul400ul£626.00
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Further Information

Additional Names:
Septin-2, Neural precursor cell expressed developmentally down-regulated protein 5, NEDD-5, SEPT2, DIFF6, KIAA0158, NEDD5
Application Note:
For WB starting dilution is: 1:1000
Background:
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.
Background References:
  • Martins-de-Souza, D., et al.Psychiatr Res (2010) In press :
  • Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
  • Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)
  • Shen, M., et al. Environ. Mol. Mutagen. 50(4):285-290(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Immunogen:
This SEPT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 280-309 amino acids from the C-terminal region of human SEPT2.
NCBI Gene ID #:
4735
NCBI Official Name:
Septin-2
NCBI Official Symbol:
Sep-02
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
41 kDa
Protein Accession #:
Q15019
Protein GI Number:
2500769
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
Q15019
User NOte:
Optimal dilutions for each application to be determined by the researcher.