ProSci

ITGAL Antibody

Product Code:
 
PSI-57-204
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in Jurkat cell line lysates (35ug/lane).
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Western blot analysis in Jurkat cell line lysates (35ug/lane).

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PSI-57-204-400ul400ul£626.00
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Further Information

Additional Names:
Integrin alpha-L, CD11 antigen-like family member A, Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, Leukocyte function-associated molecule 1 alpha chain, CD11a, ITGAL, CD11A
Application Note:
For WB starting dilution is: 1:1000
Background:
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.
Background References:
  • Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
  • Kuwano, Y., et al. Blood 116(4):617-624(2010)
  • Ghannam, S., et al. J. Immunol. 185(1):302-312(2010)
  • Quist, S.R., et al. Acta Derm. Venereol. 90(4):429-430(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This ITGAL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 722-751 amino acids from the Central region of human ITGAL.
NCBI Gene ID #:
3683
NCBI Official Name:
Integrin alpha-L
NCBI Official Symbol:
ITGAL
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
129 kDa
Protein Accession #:
P20701
Protein GI Number:
88911345
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology,Signal Transduction
Swissprot #:
P20701
User NOte:
Optimal dilutions for each application to be determined by the researcher.