Further Information
Receptor-type tyrosine-protein phosphatase N2, R-PTP-N2, Islet cell autoantigen-related protein, IAR, ICAAR, Phogrin, PTPRN2, KIAA0387
For WB starting dilution is: 1:1000
The protein encoded by this gene is a member of the
protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes
including cell growth, differentiation, mitotic cycle, and
oncogenic transformation. This PTP possesses an extracellular
region, a single transmembrane region, and a single intracellular
catalytic domain, and thus represents a receptor-type PTP. The
catalytic domain of this PTP is most closely related to
PTPRN/IA-2beta. This PTP and PTPRN are both found to be major
autoantigens associated with insulin-dependent diabetes mellitus.
Three alternatively spliced transcript variants of this gene, which
encode distinct proteins, have been reported.
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
- Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This PTPRN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-189 amino acids from the N-terminal region of human PTPRN2.
5799
Receptor-type tyrosine-protein phosphatase N2
PTPRN2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
111 kDa
Q92932
116242738
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunology,Signal Transduction
Q92932
Optimal dilutions for each application to be determined by the researcher.