ProSci

ATL1 Antibody

Product Code:
 
PSI-58-730
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in NCI-H292 cell line lysates (35ug/lane).
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Western blot analysis in NCI-H292 cell line lysates (35ug/lane).

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PSI-58-730-400ul400ul£626.00
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Further Information

Additional Names:
Atlastin-1, 365-, Brain-specific GTP-binding protein, GTP-binding protein 3, GBP-3, hGBP3, Guanine nucleotide-binding protein 3, Spastic paraplegia 3 protein A, ATL1, GBP3, SPG3A
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.
Background References:
  • Cirulli, E.T., et al. Eur. J. Hum. Genet. 18(7):815-820(2010)
  • Park, S.H., et al. J. Clin. Invest. 120(4):1097-1110(2010)
  • Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
  • de Leva, M.F., et al. J. Neurol. 257(3):328-331(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Monkey, Mouse, Rat
Immunogen:
This ATL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 477-504 amino acids from the C-terminal region of human ATL1.
NCBI Gene ID #:
51062
NCBI Official Name:
Atlastin-1
NCBI Official Symbol:
ATL1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
64 kDa
Protein Accession #:
Q8WXF7
Protein GI Number:
37999727
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience
Swissprot #:
Q8WXF7
User NOte:
Optimal dilutions for each application to be determined by the researcher.