Metabotropic Glutamate Receptor 7 Antibody
Antibody Isotype:
Rabbit Ig
Antibody Clonality:
Polyclonal
Applications:- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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Further Information
Metabotropic glutamate receptor 7, mGluR7, GRM7, GPRC1G, MGLUR7
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined.
- Schulz, H.L., et al., Neurosci. Lett. 326(1):37-40 (2002).
- Flor, P.J., et al., Neuropharmacology 36(2):153-159 (1997).
- Makoff, A., et al., Brain Res. Mol. Brain Res. 40(1):165-170 (1996).
- Scherer, S.W., et al., Genomics 31(2):230-233 (1996).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Mouse, Rat
This Metabotropic Glutamate Receptor 7 (GPRC1G) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 857-887 amino acids from the C-terminal region of human Metabotropic Glutamate Receptor 7 (GPRC1G).
2917
Metabotropic glutamate receptor 7
GRM7
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
102 kDa
Q14831
2495078
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Neuroscience,Growth Factor
Q14831
Optimal dilutions for each application to be determined by the researcher.