ProSci

ABCC5 Antibody

Product Code:
 
PSI-63-526
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Fluorescence-activated cell sorting (FACS)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis of ABCC5 Antibody in 293 cell line lysates (35ug/lane)(2ug/ml)
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Formalin-fixed and paraffin-embedded human brain tissue with ABCC5 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
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Western blot analysis of ABCC5 Antibody in 293 cell line lysates (35ug/lane)(2ug/ml)
Formalin-fixed and paraffin-embedded human brain tissue with ABCC5 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

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PSI-63-526-400ul400ul£626.00
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Further Information

Additional Names:
Multidrug resistance-associated protein 5, ATP-binding cassette sub-family C member 5, Multi-specific organic anion transporter C, MOAT-C, SMRP, pABC11, ABCC5, MRP5
Application Note:
For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

For FACS starting dilution is: 1:10~50
Background:
ABCC5 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs,6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients.
Background References:
  • Olsen,J.V., et.al., Cell 127 (3), 635-648 (2006)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This ABCC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 625-652 amino acids from the Central region of human ABCC5.
NCBI Gene ID #:
10057
NCBI Official Name:
Multidrug resistance-associated protein 5
NCBI Official Symbol:
ABCC5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
161 kDa
Protein Accession #:
O15440
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
O15440
User NOte:
Optimal dilutions for each application to be determined by the researcher.