ProSci

DCPS Antibody

Product Code:
 
PSI-58-947
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in NCI-H460 cell line lysates (35ug/lane).
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Western blot analysis in NCI-H460 cell line lysates (35ug/lane).

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PSI-58-947-400ul400ul£626.00
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Further Information

Additional Names:
m7GpppX diphosphatase, DCS-1, Decapping scavenger enzyme, Hint-related 7meGMP-directed hydrolase, Histidine triad nucleotide-binding protein 5, Histidine triad protein member 5, HINT-5, Scavenger mRNA-decapping enzyme DcpS, DCPS, DCS1, HINT5
Application Note:
For WB starting dilution is: 1:1000
Background:
Necessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA fragments shorter than 10 nucleotides that are produced by 3'->5' exosome-mediated mRNA decay. Releases m7GMP. Can also degrade m7GDP to m7GMP. Has no activity towards mRNA molecules longer than 25 nucleotides.
Background References:
  • Sebastiani, P., et al. Science (2010) In press :
  • Mariller, C., et al. Biochimie 91(1):109-122(2009)
  • Liu, S.W., et al. J. Biol. Chem. 283(24):16427-16436(2008)
  • Shen, V., et al. RNA 14(6):1132-1142(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig, Rat
Immunogen:
This DCPS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-193 amino acids from the Central region of human DCPS.
NCBI Gene ID #:
28960
NCBI Official Name:
m7GpppX diphosphatase
NCBI Official Symbol:
DCPS
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
39 kDa
Protein Accession #:
Q96C86
Protein GI Number:
116241325
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q96C86
User NOte:
Optimal dilutions for each application to be determined by the researcher.