ProSci

JHDM1a/FBXL11 Antibody

Product Code:
 
PSI-55-180
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
1 / 3
Formalin-fixed and paraffin-embedded human testis tissue reacted with JHDM1a/FBXL11 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
2 / 3
Western blot analysis of JHDM1a/FBXL11 using rabbit polyclonal JHDM1a/FBXL11 Antibody.293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the JHDM1a/FBXL11 gene (Lane 2).
3 / 3
❮❯

Formalin-fixed and paraffin-embedded human testis tissue reacted with JHDM1a/FBXL11 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Western blot analysis of JHDM1a/FBXL11 using rabbit polyclonal JHDM1a/FBXL11 Antibody.293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the JHDM1a/FBXL11 gene (Lane 2).

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PSI-55-180-400ul400ul£626.00
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Further Information

Additional Names:
Lysine-specific demethylase 2A, CXXC-type zinc finger protein 8, F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, F-box/LRR-repeat protein 11, JmjC domain-containing histone demethylation protein 1A, [Histone-H3]-lysine-36 demethylase 1A, KDM2A, CXXC8, FBL7, FBXL11, JHDM1A, KIAA1004
Application Note:
For IHC-P starting dilution is: 1:10~50

For WB starting dilution is: 1:1000
Background:
JHDM1a/FBXL11 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least 6 highly degenerated leucine-rich repeats.
Background References:
  • Tsukada,Y.,Nature 439 (7078), 811-816 (2006)
  • Andersen,J.S.,Nature 433 (7021), 77-83 (2005)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This JHDM1a/FBXL11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 500-527 amino acids from the Central region of human JHDM1a/FBXL11.
NCBI Gene ID #:
22992
NCBI Official Name:
Lysine-specific demethylase 2A
NCBI Official Symbol:
KDM2A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
133 kDa
Protein Accession #:
Q9Y2K7
Protein GI Number:
38257795
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Swissprot #:
Q9Y2K7
User NOte:
Optimal dilutions for each application to be determined by the researcher.