ProSci

IBTK Antibody

Product Code:
 
PSI-55-375
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Fluorescence-activated cell sorting (FACS)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
1 / 3
Western blot analysis in MDA-MB435 cell line lysates (35ug/lane).
2 / 3
IBTK antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human lymph tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
3 / 3
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Western blot analysis in MDA-MB435 cell line lysates (35ug/lane).
IBTK antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human lymph tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.

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PSI-55-375-400ul400ul£626.00
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Further Information

Additional Names:
Inhibitor of Bruton tyrosine kinase, IBtk, IBTK, BTKI, KIAA1417
Application Note:
For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

For FACS starting dilution is: 1:10~50
Background:
The protein encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription.
Background References:
  • Fiume, G., et al. Comput Biol Chem 33(6):434-439(2009)
  • Spatuzza, C., et al. Nucleic Acids Res. 36(13):4402-4416(2008)
  • Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
  • Olsen, J.V., et al. Cell 127(3):635-648(2006)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This IBTK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-613 amino acids from the Central region of human IBTK.
NCBI Gene ID #:
25998
NCBI Official Name:
Inhibitor of Bruton tyrosine kinase
NCBI Official Symbol:
IBTK
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
151 kDa
Protein Accession #:
Q9P2D0
Protein GI Number:
134034141
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q9P2D0
User NOte:
Optimal dilutions for each application to be determined by the researcher.