ProSci

DOK7 Antibody

Product Code:
 
PSI-57-126
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in mouse spleen tissue lysates (35ug/lane).
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Western blot analysis in mouse spleen tissue lysates (35ug/lane).

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PSI-57-126-400ul400ul£626.00
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Further Information

Additional Names:
Protein Dok-7, Downstream of tyrosine kinase 7, DOK7, C4orf25
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants.
Background References:
  • Bergamin, E., et al. Mol. Cell 39(1):100-109(2010)
  • Srour, M., et al. Neuromuscul. Disord. 20(7):453-457(2010)
  • Maselli, R.A., et al. Hum. Mol. Genet. 19(12):2370-2379(2010)
  • Ben Ammar, A., et al. J. Neurol. 257(5):754-766(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This DOK7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human DOK7.
NCBI Gene ID #:
285489
NCBI Official Name:
Protein Dok-7
NCBI Official Symbol:
DOK7
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
53 kDa
Protein Accession #:
Q18PE1
Protein GI Number:
115311705
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q18PE1
User NOte:
Optimal dilutions for each application to be determined by the researcher.