ProSci

IL-37 Recombinant Protein

Product Code:
 
PSI-96-901
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-901-0.05mg0.05mg£597.00
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Further Information

Additional Names:
IL1F7,IL37,FIL1Z,IL1H4,IL1RP1
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Interleukin-1 family member 7 (IL1F7b) ,a member of the IL-1 family, is aslo known as interleukin-37, interleukin-1 homolog 4 (IL-1H4), interleukin-1 zeta (IL-1 zeta) and interleukin-1-related protein, which can interact with SMAD3 and bind to IL18R1, but not to IL1R1, with lower affinity than IL18. IL1F7b is a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Therefore,IL1F7b can suppress, or reduce, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spare anti-inflammatory cytokines. Furthermore,IL1F7b can also inhibit dendritic cell activation.
Background References:
  • Pan G., et al., 2001, Cytokine 13:1-7.
  • Sharma S., et al., 2008, J. Immunol. 180:5477-5482.
  • Nold M.F., et al., 2010, Nat. Immunol. 11:1014-1022.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
27178
NCBI Official Name:
Interleukin 1 family, member 7 (zeta)
NCBI Official Symbol:
IL-37
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
20.3 kDa
Protein Accession #:
AAH20637
Purity:
>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
Q9NZH6-1

Documents