ProSci

IL-17F Recombinant Protein

Product Code:
 
PSI-96-897
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-897-0.02mg0.02mg£469.00
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Further Information

Additional Names:
IL-17F,IL24,ML-1,Interleukin-17F
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Interleukin-17F (IL17F) is also known as Interleukin-24 (IL24), Cytokine ML-1, is a secreted disulfide-linked homodimer which belongs to the IL-17 family. There are at least six members of the IL-17 family in humans and in mice: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25) and IL-17F (also called IL-24). IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. IL-17F / IL-24 is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. IL17F / Interleukin-24 stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. IL17F / IL-24 stimulates PBMC and T-cell proliferation and Inhibits angiogenesis. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6).
Background References:
  • Kolls JK, et al., 2004, Immunity 21 (4): 467?76.
  • Ely L.K., et al., 2009, Nat. Immunol. 10:1245-1251.
  • Puel A., et al., 2011, Science 332:65-68.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
112744
NCBI Official Name:
Interleukin 17F
NCBI Official Symbol:
IL-17F
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
15.7 kDa
Protein Accession #:
AAH70124
Purity:
>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q96PD4

Documents