ProSci

ADAM17 Recombinant Protein

Product Code:
 
PSI-96-968
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-968-0.05mg0.05mg£867.00
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Further Information

Additional Names:
ADAM17,TACE,CD156b
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), a member of the ADAM protein family of disintegrins and metalloproteases, is also known as TNF-alpha convertase, TNF-alpha-converting enzyme and CD156b, which contains one disintegrin domain and one peptidase M12B domain. ADAM17 can cleave the membrane-bound precursor of TNF-alpha to its mature soluble form. ADAM17 is also responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity) and proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Furthermore, ADAM17 acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation.
Background References:
  • Black R., et al., 1997, Nature 385 (6618): 729?33
  • Moss M., et al., 1997, Nature 385 (6618): 733?6
  • Schroeter E., et al., 1998, Nature 393 (6683): 382?6.
Buffer:
50 mM MES, 150 mM NaCl, pH6.5
Fusion Tag:
His Tag
NCBI Gene ID #:
11491
NCBI Official Name:
Disintegrin and metalloproteinase domain-containing protein 17
NCBI Official Symbol:
ADAM17
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Predicted Molecular Weight:
63.4 kDa
Protein Accession #:
Q9Z0F8
Purity:
>90% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q9Z0F8

Documents