ProSci

CD4 Recombinant Protein

Product Code:
 
PSI-97-059
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Rhesus Macaque
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-97-059-0.1mg0.1mg£597.00
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Further Information

Additional Names:
CD4,CD4mut,LEU3
Application Note:
This recombinant protein can be used for E, WB. For research use only.
Background:
T-cell surface glycoprotein CD4 is also known as T-cell surface antigen T4/Leu-3. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is accessory protein for MHC class-II antigen/T-cell receptor interaction. CD4 induces the aggregation of lipid rafts. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors. Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients.
Background References:
  • Brady RL, et al., 1993, Science 260 (5110): 979?83.
  • Zeitlmann, L., et al., 2001, J. Biol. Chem. (United States) 276 (12): 9123?32.
  • Rudd CE, et al., 2010, J. Immunol. 185 (5): 2645?9.
  • Rudd CE, et al., 1988, Proc. Natl. Acad. Sci. U.S.A. 85 (14): 5190?4.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized HIV GP120 (HIV), His Tag at 10 ug/mL (100 uL/well) can bind Rhesus macaque CD4, Fc Tag with a linear range of 0.04-0.31 ug/mL.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
Fc Tag
NCBI Official Symbol:
CD4
NCBI Organism:
Macaca mulatta
Physical State:
Lyophilized
Predicted Molecular Weight:
67 kDa
Protein Accession #:
G7N5T8
Purity:
>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
G7N5T8

Documents