ProSci

Neuregulin-4 Recombinant Protein

Product Code:
 
PSI-96-931
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-931-0.05mg0.05mg£729.00
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Further Information

Additional Names:
Neuregulin-4,NRG4
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene. Loss of expression of NRG4 is frequently seen in advanced bladder cancer while increased NRG4 expression correlates to better survival. The neuregulins, including NRG4, activate type-1 growth factor receptors (EGFR) to initiating cell-to-cell signaling through tyrosine phosphorylation. Furthermore, NRG4 is a low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG4 does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
Background References:
  • Memon AA., et al., 2004, Br J Cancer. 91(12):2034-41.
Buffer:
50 mM Tris, 100 mM NaCl, pH7.5
Fusion Tag:
His Tag
NCBI Gene ID #:
145957
NCBI Official Name:
Pro-neuregulin-4
NCBI Official Symbol:
Neuregulin-4
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
8.6 kDa
Protein Accession #:
Q8WWG1
Purity:
>90% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q8WWG1

Documents