NSJ Bioreagents

Anti-Caspase-8 Antibody

Product Code:
 
NSJ-R30365
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application:
 
Western Blot (WB)
Storage:
 
After reconstitution, the anti-Caspase-8 antibody can be stored for up to one month at 40. For long-term, aliquot and store at -200. Avoid repeated freezing and thawing.
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Western blot testing of anti-Caspase-8 antibody and Lane 1: rat thymus; 2: rat liver; 3: MCF-7; 4: HeLa; 5: SMMC-7721
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Western blot testing of anti-Caspase-8 antibody and Lane 1: rat thymus; 2: rat liver; 3: MCF-7; 4: HeLa; 5: SMMC-7721

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NSJ-R30365-100ug100 ug£535.00
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Further Information

Application Details :
Western blot: 0.5-1ug/ml
Application Note:
The stated application concentrations are suggested starting points. Titration of the anti-Caspase-8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases including CASP3/4/6/7/9/10. [UniProt]
Format :
Antigen affinity purified
Formulation :
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Immunogen:
Amino acids 240-259 (DKVYQMKSKPRGYCLIINNH-human) were used as the immunogen for this anti-Caspase-8 antibody. This sequence is from the large subunit.
Limitation:
This anti-Caspase-8 antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human, Mouse, Rat
Uniprot #:
Q14790