NSJ Bioreagents

BCR Antibody / Breakpoint cluster region protein

Product Code:
 
NSJ-R32473
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application:
 
Western Blot (WB)
Storage:
 
Prior to reconstitution, store at 40. After reconstitution, the BCR antibody can be stored for up to one month at 40. For long-term, aliquot and store at -200. Avoid repeated freezing and thawing.
1 / 3
Immunofluorescent staining of FFPE human A431 cells with BCR antibody (green) and DAPI nuclear stain (blue). HIER: steam section in pH6 citrate buffer for 20 min.
2 / 3
Flow cytometry testing of human HL60 cells with BCR antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= BCR antibody.
3 / 3
Western blot testing of 1) human K562, 2) human 293T, 3) human HepG2, 4) rat brain and 5) mouse brain lysate with BCR antibody at 0.5ug/ml. Expected molecular weight: 130-190 kDa (multiple isoforms).
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Immunofluorescent staining of FFPE human A431 cells with BCR antibody (green) and DAPI nuclear stain (blue). HIER: steam section in pH6 citrate buffer for 20 min.
Flow cytometry testing of human HL60 cells with BCR antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= BCR antibody.
Western blot testing of 1) human K562, 2) human 293T, 3) human HepG2, 4) rat brain and 5) mouse brain lysate with BCR antibody at 0.5ug/ml. Expected molecular weight: 130-190 kDa (multiple isoforms).

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CodeSizePrice
NSJ-R32473-100ug100 ug£535.00
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Further Information

Application Details :
Western blot: 0.5-1ug/ml,Immunofluorescence (FFPE): 5ug/ml,Flow cytometry: 1-3ug/million cells
Buffer:
Lyophilized from 1X PBS with 2% Trehalose
Description:
The breakpoint cluster region protein (BCR) is a protein that in humans is encoded by the BCR gene. A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
Format :
Antigen affinity purified
Formulation :
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Immunogen:
Amino acids M1-A100 from the human protein were used as the immunogen for the BCR antibody.
Limitation:
This BCR antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human, Mouse, Rat
Uniprot #:
P11274