NSJ Bioreagents

IRS-1 Antibody

Product Code:
 
NSJ-R31393
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application:
 
Western Blot (WB)
Storage:
 
After reconstitution, the IRS-1 antibody can be stored for up to one month at 40. For long-term, aliquot and store at -200. Avoid repeated freezing and thawing.
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Western blot testing of IRS-1 antibody and Lane 1: HeLa; 2: A549; 3: 293T; 4: MCF-7 lysate, Expected size: 132~185KD depending on serine phosphorylation level
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Western blot testing of IRS-1 antibody and Lane 1: HeLa; 2: A549; 3: 293T; 4: MCF-7 lysate, Expected size: 132~185KD depending on serine phosphorylation level

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NSJ-R31393-100ug100 ug£535.00
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Further Information

Application Details :
Western blot: 0.5-1ug/ml
Application Note:
The stated application concentrations are suggested starting amounts. Titration of the IRS-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Insulin receptor substrate 1 is a signalling adapter protein that in humans is encoded by the IRS1 gene. This gene exhibited no intrinsic enzyme activity, and it can serve as a docking protein involved in binding and activating other signal transduction molecules after being phosphorylated on tyrosine by insulin receptor kinase. IRS-1 plays a key role in transmitting signals from the insulin and insulin-like growth factor-1 (IGF-1) receptors to intracellular pathways PI3K/Akt and Erk MAP kinase pathways. It also plays important biological function for both metabolic and mitogenic (growth promoting) pathways. In addition to those, IRS-1 is a key regulator of PI3K within malignant cells.
Format :
Antigen affinity purified
Formulation :
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Immunogen:
An amino acid sequence from the N-terminus of mouse Insulin receptor substrate 1 (WYQALLQLHNRAKAHHD) was used as the immunogen for this IRS-1 antibody (100% rat homology).
Limitation:
This IRS1 antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human, Mouse, Rat
Uniprot #:
P35569