NSJ Bioreagents

Kallikrein 6 Antibody

Product Code:
 
NSJ-R30860
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunocytochemistry (ICC)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
After reconstitution, the Kallikrein 6 antibody can be stored for up to one month at 40. For long-term, aliquot and store at -200. Avoid repeated freezing and thawing.
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Western blot testing of Kallikrein 6 antibody and Lane 1: MCF-7; 2: HeLa; 3: MM231; 4: MM453; 5: A549; 6: SMMC-7721; 7: COLO320; 8: SW620; 9: HT1080
2 / 3
IHC-P: Kallikrein 6 antibody testing of human intestinal cancer tissue
3 / 3
ICC testing of rat PC3 cells
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Western blot testing of Kallikrein 6 antibody and Lane 1: MCF-7; 2: HeLa; 3: MM231; 4: MM453; 5: A549; 6: SMMC-7721; 7: COLO320; 8: SW620; 9: HT1080
IHC-P: Kallikrein 6 antibody testing of human intestinal cancer tissue
ICC testing of rat PC3 cells

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NSJ-R30860-100ug100 ug£535.00
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Further Information

Application Details :
Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml,Immunocytochemistry: 0.5-1ug/ml
Application Note:
The stated application concentrations are suggested starting amounts. Titration of the Kallikrein 6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Kallikrein-related peptidase 6 is a protein that in humans is encoded by the KLK6 gene. This gene is one of the fifteen subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. Northern blot analysis revealed that the PRSS9 mRNA was expressed in several primary tumors and cell lines from mammary, prostate, and ovarian cancers, but was not detected in any metastases of these cancers. The KLK6 gene is mapped on 19q13.41. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimers disease. Upon cellular stress, neurosin was released from mitochondria to the cytosol, which resulted in the increase of degraded alpha-synuclein species. Neurosin may play a significant role in physiologic alpha-synuclein degradation and also in the pathogenesis of synucleinopathies.
Format :
Antigen affinity purified
Formulation :
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Immunogen:
An amino acid sequence from the C-terminus of human KLK6 (YTNVCRYTNWIQKTIQAK) was used as the immunogen for this Kallikrein 6 antibody.
Limitation:
This Kallikrein 6 antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human
Uniprot #:
Q92876