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Most popular inhibitors by TargetMol: - PI3K/Akt/mTOR signaling - Angiogenesis - Proteases/Proteasome - MAPK - Stem Cells - Ubiquitination - Cell Cycle/Checkpoint - DNA Damage/DNA Repair - Microbiology and Virology - Apoptosis - NF-kb - GPCR/G Protein
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Small Molecules
TargetMol
Drug repurposing, also known as the new use of old drugs, is a strategic approach to discover new applications for old or investigational drugs beyond their original approved applications. While the development of new drugs is a process with a high failure rate, high cost, and slow pace, repositioning old drugs for common and rare diseases is becoming increasingly attractive because of the advantages of low R&D costs and short development time.
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Small Molecules
TargetMol
Cell Counting Kit-8 allows convenient assays using WST-8, which produces a water-soluble formazan dye upon reduction in the presence of an electron carrier, 1-Methoxy PMS.
Documents
Cell Based Assays
TargetMol
Primary PBMCs from Cell Generation are isolated directly from peripheral blood of eligible donors via leukapheresis procedure. Leukapheresis performed following Institutional Review Board (IRB) consented healthy or diseased human donors.
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Biological Samples
Cell Generation
IDH1/2 Mutations
Documents
Cancer
Abnova Corporation
Androgen receptor (AR) is a member of the steroid receptor transcription factor family. In prostate cancer, increased levels of androgens in the tumor cells promote (1) AR signaling associated with cell-cycle regulation, growth, and survival, and (2) the expression of oncogenic fusion genes. AR-V7 is one of the splice variants of AR lacking the C-terminal LBD, but being constitutively active as a transcription factor and capable of promoting activation of target genes.
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Cancer
Abnova Corporation
Inactive monomeric heat shock factor 1 (HSF1) exists predominantly in the cytoplasm and remains repressed by complex with regulatory proteins of HSF1 its own transcriptional targets of heat-shock protein (HSP) and cytosolic chaperonin TCP1 ring complex (TRiC). Upon a wide range of stress conditions, HSF1 is activated to undergo trimerization, nuclear translocation, and post-translational modifications (PTMs) including phosphorylation, acetylation, and sumoylation, converted into a DNA-binding-competent, active homotrimer. HSF1 is then modified by different inhibitory PTMs to cause DNA dissociation, HSF1 inactivation, and HSF1 recycling/degradation and maintained in a negative-feedback mechanism.
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Antibodies
Abnova Corporation
High IF Literature in October, 2022
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Flow Cytometry
Elabscience
High IF Literature in November, 2022.
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Flow Cytometry
Elabscience
Complement System ELISA Kits - Complement Components, Complement Regulators, Complement Receptors and Complement Lectin Pathway Targets from Abnova.
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ELISA
Abnova Corporation
Popular ELISA & Assay Kits
Documents
Kits
Abnova Corporation
Microglia Function Transition.
Documents
Antibodies
Abnova Corporation
NLRP3 activation can occur through both potassium-dependent and potassium-independent mechanisms. Potassium-dependent mechanisms depend on potassium efflux upon MLKL activation, opening of P2X7 channel or exposure to pore-forming toxins. Potassium-independent activation is mediated through metabolic perturbation.
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Inflammation
Abnova Corporation
Full-length mutant huntingtin (mHTT) can be further processed to generate smaller fragments and the amino-terminal HTT exon1 protein fragments are formed by aberrant splicing. Fragments can undergo self-association, oligomerization, and aggregation in the nucleus and cytoplasm, leading to the formation of inclusions that cause numerous pathogenic mechanisms, including synaptic dysregulation, mitochondrial toxicity, energy imbalance, and impaired axonal transport in Huntington’s disease.
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Antibodies
Abnova Corporation
Inhibition of BAK Activation in the Microenvironment. B cell receptor associated kinases (BAKs) are expressed in not only B cells but also other cell types, and regulate the signaling of other surface receptors within the tumor microenvironment (TME). Evidence has suggested that BAK inhibitors could disrupt the crosstalk between malignant B cells and their microenvironment by suppressing the function of BAKs in those non-tumor cells.
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Kinase
Abnova Corporation
While several studies discovered the therapeutic potential of receptor tyrosine kinase (RTK) inhibition, research has recently put a spotlight on novel kinase targets that influence basal cellular process in cancer. Cyclin-dependent kinase (CDK) is one of the new areas that has been focused. As transcription-associated kinases, CDKs represent opportunities for the development of druggable targets for transcriptional-addicted cancers.
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Kinase
Abnova Corporation
Tumor-Associated Antigens of CAR T Cell Therapy
Documents
Antibodies
Abnova Corporation
Immunoglobulin ELISA Kits
Documents
ELISA
Abnova Corporation
Several PD-associated genes interact with pathways regulating mitochondrial homeostasis. The mutations in these genes encoding proteins, like VPS35, PINK1 and LRRK2, lead to mitochondrial dysfunction and further drive the development of neurodegeneration in PD.
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Proteins
Abnova Corporation
Cell culture has become essential to small and large scale monoclonal antibody productions. Abnova uses a specialized protocol for generating cell culture grade antibodies. Compared to classic cell culture, this method allows for multiple harvests, longer run times and higher concentrated supernatant, and provides customers high purified antibodies with minimal to zero contamination.
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Antibodies
Abnova Corporation
Abnova have over 300 camelid single domain antibodies (sdAbs), derived from alpacas or llamas, with great penetrability and affinity to recognize difficult epitopes. The product lines include FluoTag-Q, FluoTag-X2 and FluoTag-X4, featuring different number of sdAb and coupled fluorophore.
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Antibodies
Abnova Corporation
On February 11, 2020, the novel coronavirus which, at the end of 2019, had been identified as causing severe respiratory disease, was officially named 'Coronavirus Disease 2019'. What is Abnova’s action to support the global response to COVID-19? They offer a range of tools to assist researchers in accelerating infectious disease research, and help healthcare workers deal with the high demand for testing.
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COVID-19
Abnova Corporation
A list of Abnova antibodies, proteins and ELISA kits that are specific for Coronaviruses.
Documents
Antibodies
Abnova Corporation
Abnova offers recombinant human monoclonal antibodies raised against various SARS-CoV or SARS-CoV-2 proteins. These antibodies include humanized and fully human monoclonal antibodies which are much less immunogenic than the original mouse antibodies, but have improvement in their activation of the human immune system.
Documents
Antibodies
Abnova Corporation
Abnova offers RNA markers for precise size determination of double-strand or single strand RNA molecules in denaturing acrylamide gels. These RNA markers consist of RNA transcripts with various size ranges, which are useful for estimating the amount of RNA samples based on your research needs.
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RNA
Abnova Corporation