Epidermal Levels of Staphylococcus Aureus Are Affected by a Peptide Produced by Other Skin Dwelling Bacteria
Staphylococcus aureus is common to many of people’s ski
n microbiome, and is generally harmless; however, in high population density the bacteria can lead to atopic dermatitis. The study shows that other species of Staphylococcus, including S. epidermidis (on right) and S. hominis are capable of producing strain specific peptides to regulate S. aureus growth. Check out this paper that highlights how the microbes we carry every day help to keep our skin healthy.
Mapping Cancer Tissues in 3 Dimensions
Molecular biologists, astronomers, and video game designers have teamed up to build a virtual reality program used to explore tumor tissue in breast cancer. Their goal is to be able to perform single cell sequence analysis using imaging techniques that allow them to identify thousands of RNAs and close to 50 proteins present in individual cells. On top of this vast bank of information, the visuals they create to study these tissues are quite appealing:take a look!
Engineered Human Chimeric Antigen Receptor T Cells to Prevent Exhaustion and Improve the Efficacy of Immunotherapy
T-cell exhaustion has been highlighted as one of the main roadblocks to the long-term success of immunotherapy. The prospect of modifying the expression of T cells so that exhaustion-associated inhibition is limited has already seen promising results in patients with CD19-expressing B-cell acute leukaemias. The paper explains that T cell exhaustion problems may be of greater issue in solid tumors, and how the new method of genetic modification used is much safer than earlier techniques, such as viral integration. Image of a bispecific chimeric antigen receptor, like those discussed here.
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