AdipoGen Life Sciences has developed a sensitive and specific colourimetric sandwich ACE2 (human) ELISA Kit (Prod. No. AG-45B-0023) that can be used for the in vitro quantitative determination of soluble human ACE2 in cell culture supernatants, serum, plasma and urine.
ACE2 has been identified as a key receptor on target cells for SARS-CoV infections in 2002. ACE2 functions as the entry receptor of the new SARS-CoV-2 coronavirus that emerged in China in 2019 and is the cause of the new disease COVID-19. Strong binding of the spike protein of SARS-CoV-2 to ACE2, along with proteolytic cleavage of ACE2 by transmembrane serine protease 2 (TMPRSS2), facilitates entry of the virus into cells, viral replication and cell-to-cell transmission. ACE2 can undergo an ADAM17 (a disintegrin and metalloproteinase 17)-mediated “shedding” from endothelial cells, resulting in the release of the ectodomain into the circulation. This soluble form may act as a competitive interceptor of SARS-CoV-2 and other coronaviruses by preventing the binding of the viral particle to the surface-bound, full-length ACE2. A reliable ELISA Kit to determine soluble ACE2 in the circulation can be useful in therapeutic developmental studies.
Soluble ACE2 might also be used as a biomarker of hypertension and cardiovascular diseases.
Originally posted on adipogen.com/covid-19
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