KACTUS - High-Quality Recombinant Proteins and Enzymes that Accelerate Therapeutic Development - Distributed in the UK and Ireland by Caltag Medsystems
KACTUS
KACTUS is a recombinant protein and enzyme manufacturer, offering 3,000 off-the-shelf catalogue proteins. As the first company to express full-length Claudin 18.2, KACTUS has always embraced complex protein expression challenges. This has resulted in their catalogue of challenging proteins, such as MHC-peptide complexes, membrane proteins and gene editing enzymes. Additionally, their catalogue offers a broad range of proteins and enzymes for antibody drug discovery, cell therapy, gene therapy and RNA therapeutics.
KACTUS' proteins come in a variety of species, tags and labels, ensuring they meet the diverse needs of researchers. They manufacture their products in-house, using primarily mammalian expression systems to ensure proper protein folding and post-translational modifications. After expression, KACTUS performs rigorous quality control testing for purity and bioactivity using analytical techniques such as SPR, ELISA and SEC-HPLC. Each protein in their catalogue is approved based on its performance, consistency and stability of supply. This ensures a recombinant protein catalogue committed to both quality and reliability.
As confirmation of KACTUS' quality, they are ISO13485 certified and hold FDA Drug Master File Certifications.
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MHC Monomers & Tetramers
KACTUS has successfully developed a series of MHC complexes, including monomers, tetramers, chimeric MHCs and peptide-ready MHCs, as well as related custom services, fully supporting the development of tumour immunotherapy drugs. Their MHC complex portfolio covers popular antigens such as NY-ESO-1, KRAS, AFP, and HPV16, as well as various Class I alleles. These MHC products can be used to meet the diverse needs of immunology, molecular screening, TCR affinity validation, blocking assays and other applications.
MHC Product Features
- Extensive catalogue of products
- Extensive choice of Alleles
- Verified bioactivity
- Mammalian & coli expression systems
- Biotinylation & Fluorescent Labels
MHC Product Portfolio
Recombinant Proteins
KACTUS offers a large selection of recombinant proteins for research and drug development. This includes applications such as antibody screening, binding studies, immunotherapy development, analytical assays and basic research. Their proteins are typically expressed from HEK293 mammalian systems to ensure proper folding and glycosylation. Before entering the catalogue, KACTUS' products undergo thorough quality control testing for bioactivity and purity using assays such as SPR, ELISA, SEC-HPLC and Bis-Tris PAGE. Choose from various species (human, mouse, cynomolgus, rhesus macaque, canine, etc), tags (His, His-Avi, hFc, mFc) and labels (biotinylation, fluorescence) to meet your specific applications.
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Enzymes – GMP & RUO
KACTUS offers a selection of recombinant enzymes in both research-grade and GMP-grade for gene editing, biologics manufacturing, RNA production and DNA production. Their off-the-shelf gene editors, AccuBase® Base Editor and Cas9 Protein, are manufactured according to cGMP standards and provide high gene editing efficiency. Additionally, they offer a Serratia marcescens nuclease, MaxNuclease™, for nucleic acid removal in biologics workflows. Finally, they offer catalogue enzymes for RNA production and in vitro DNA synthesis. KACTUS' enzymes have verified activity, batch consistency and purity and are available at small and large scales with a consistent, long-term supply.
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Assay Kits
The team at KACTUS has developed a series of off-the-shelf assay kits for various applications. Their AAV Titration ELISA kits quantify intact AAV capsids for individual serotypes (2/5/6/8/9) with high specificity and sensitivity. Additionally, their Cas9 ELISA kit can be used to detect residual Cas9 protein in edited cells with high accuracy. This kit has been validated with various wild-type and engineered Cas9 proteins with consistent detection. KACTUS ELISA kits use recombinant monoclonal antibodies to ensure consistency.
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KACTUS' Products by Application
Target Proteins for Drug Discovery
- Immune Checkpoint Proteins
- Fc Receptor Proteins
- CAR-T Therapy Proteins
- CD3 Proteins
- Integrin Proteins
- Cadherin Proteins
Gene Editing Enzymes
- AccuBase® – The Next Generation Base Editor
- Cas9 Protein – The classic CRISPR Workhorse
Products for Cell Therapy
- MHC Monomers & Tetramers
- CAR-T Proteins
- Cytokines for Cell Culture
Custom Services
KACTUS specialise in providing customised solutions for recombinant protein production. Whether you require modifications to existing proteins or entirely novel constructs, they are committed to delivering active, efficient and scalable results. Their recombinant protein production experience, along with their proprietary SAMS™ platform, will ensure your product has the optimal configuration and expression conditions for bioactivity and purity.
Popular Custom Solutions
Membrane Proteins
Custom membrane proteins displayed on VLPs or Nanodiscs.
MHC Custom Services
Custom MHC Class I & II molecules, crucial for immunotherapy research.
Soluble TCR Expression
Soluble TCR Expression services with engineering and optimisation of various formats of TCRs.
SPR Analysis Services
Characterisation of biomolecular interactions using Surface Plasmon Resonance technology.
Solute Carrier Proteins
Custom solute carrier protein expression services displayed on VLPs or Nanodiscs.