anti-Dityrosine [DT], mAb (1C3)
| Code | Size | Price |
|---|
| JAI-MDT-020P-20ug | 20 ug | £233.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Antibody Isotype: Mouse IgG2akappa
Antibody Clonality: Monoclonal
Antibody Clone: 1C3
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
BLUE ICE
Storage:
-20°C
Documents
Further Information
EClass:
32160000
Form (Short):
liquid
Formulation:
Lyophilized. Contains 10mM PBS (pH7.4).
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
3-(p-hydroxyphenyl) propionic acid dimer-conjugated keyhole limpet hemocyanin.
Long Description:
Monoclonal Antibody. Recognizes free dityrosine, 3-(p-hydroxyphenyl) propionic acid dimer, dityrosine-BSA conjugate, and dityrosine in protein or peptides. Does not cross-react with nitrotyrosine, chlorotyrosine, aminotyrosine, phosphotyrosine, tyrosine, 3-(p-hydroxyphenyl) propionic acid, phenylalanine, 3,4-dihydroxyphenylacetic acid (DOPA). Lyophilized. Contains 10mM PBS (pH7.4). Tyrosine is one of the major targets of protein oxidation. Dityrosine (DT) is known to be formed when tyrosine is damaged by free radicals, such as reactive oxygen species (ROS), metal-catalyzed oxidation, ultraviolet irradiation, and peroxidases. Dityrosine has been found in atherosclerotic lesions, and lipofuscin of pyramidal neurons of aged human brains. Dityrosine is a specific biomarker for protein oxidation. Dityrosine is reported to exist in various tissues and was also recently detected in urine samples. It is expected to be a novel protein oxdation marker, which is non-invasively detectable.
Package Type:
Plastic Vial
Product Description:
Tyrosine is one of the major targets of protein oxidation. Dityrosine (DT) is known to be formed when tyrosine is damaged by free radicals, such as reactive oxygen species (ROS), metal-catalyzed oxidation, ultraviolet irradiation, and peroxidases. Dityrosine has been found in atherosclerotic lesions, and lipofuscin of pyramidal neurons of aged human brains. Dityrosine is a specific biomarker for protein oxidation. Dityrosine is reported to exist in various tissues and was also recently detected in urine samples. It is expected to be a novel protein oxdation marker, which is non-invasively detectable.
Specificity:
Recognizes free dityrosine, 3-(p-hydroxyphenyl) propionic acid dimer, dityrosine-BSA conjugate, and dityrosine in protein or peptides. Does not cross-react with nitrotyrosine, chlorotyrosine, aminotyrosine, phosphotyrosine, tyrosine, 3-(p-hydroxyphenyl) propionic acid, phenylalanine, 3,4-dihydroxyphenylacetic acid (DOPA).
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 3 years after receipt when stored at -20°C.
References
Immunochemical detection of protein dityrosine in atherosclerotic lesion of apo-E-deficient mice using a novel monoclonal antibody: Y. Kato, et al.; BBRC 275, 11 (2000) | The hydrogen peroxide/copper ion system, but not other metal-catalyzed oxidation systems, produces protein-bound dityrosine: Y. Kato, et al.; Free Radic. Biol. Med. 31, 624 (2001) | Copper mediates dityrosine cross-linking of Alzheimer?s amyloid-beta: C.S. Atwood, et al.; Biochemistry 43, 560 (2004) | Immunohistochemical detection of oxidative stress biomarkers, dityrosine and N(epsilon)-(hexanoyl)lysine, and C-reactive protein in rabbit atherosclerotic lesions: Y. Fukuchi, et al.; J. Atheroscler. Thromb. 15, 185 (2008) | Expressions of protein oxidation markers, dityrosine and advanced oxidation protein products in Cisplatin-induced nephrotoxicity in rats: Y. Kimoto, et al.; J. Vet. Med. Sci. 73, 403 (2011) | Effect of protein malnutrition on the skin epidermis of hairless mice: A. Sugiyama, et al.; J. Vet. Med. Sci. 73, 831 (2011) | Expressions of protein oxidation markers, dityrosine and advanced oxidation protein products in acetaminophen-induced liver injury in rats: J. Sun, et al.; J. Vet. Med. Sci. 73, 1185 (2011) | Intramolecular cross-linking in the native JHBP molecule: D. Bystranowska, et al.; Arch. Biochem. Biophys. 517, 12 (2012) | Di-tyrosine cross-link decreases the collisional cross-section of Ab peptide dimers and trimers in the gas phase: An ion mobility study: E. Sitkiewicz, et al.; PLOS One 9, e100200 (2014)
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