Cisplatin
| Code | Size | Price |
|---|
| CDX-C0320-M250 | 250 mg | £102.00 |
Quantity:
| CDX-C0320-G001 | 1 g | £304.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term Storage: +20?C. Long Term Storage: +20?C
Documents
Further Information
Alternate Names/Synonyms:
cis-Diammineplatinum(II) dichloride; cis-Dichlorodiammine platinum(II); cis-Platinum(II) diammine dichloride; Neoplatin; CDDP; cis-DDP; NSC119875
Appearance:
Yellow to orange powder.
CAS:
15663-27-1
EClass:
32160000
Form (Short):
solid
GHS Symbol:
GHS05,GHS06,GHS08
Handling Advice:
Protect from light and moisture.
Hazards:
H300-H318-H350
InChi:
InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2
InChiKey:
LXZZYRPGZAFOLE-UHFFFAOYSA-L
Long Description:
Chemical. CAS: 15663-27-1. Formula: Cl2H6N2Pt. Molecular Weight: 300.05. Cisplatin is an inorganic platinum complex with antineoplastic activity. Cisplatin is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin induces apoptosis and autophagy and activates ferroptosis. It is a potent chemoimmunotherapeutic drug and stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin effects are regulated by kinases, phosphatases, and Ca2+/calmodulin.
MDL:
MFCD00011623
Molecular Formula:
Cl2H6N2Pt
Molecular Weight:
300.05
Package Type:
Vial
PG:
II
Precautions:
P201 - P264 - P280 - P301 + P310 - P305 + P351 + P338 - P308 + P313
Product Description:
Cisplatin is an inorganic platinum complex with antineoplastic activity. Cisplatin is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin induces apoptosis and autophagy and activates ferroptosis. It is a potent chemoimmunotherapeutic drug and stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin effects are regulated by kinases, phosphatases, and Ca2+/calmodulin.
Purity:
>98% (HPLC)
Signal word:
Danger
SMILES:
Cl[Pt]([NH3])(Cl)[NH3]
Solubility Chemicals:
Soluble in DMF (10mg/ml). Slightly soluble in water (1mg/ml). Insoluble in ethanol.
Transportation:
Excepted Quantity
UN Nummer:
3288
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at RT.
References
(1) G.R. Gale, et al.; J. Natl. Cancer Inst. 51, 1227 (1973) | (2) O. Bagasra, et al.; Cancer Immunol. Immunother. 19, 142 (1985) | (3) I. Sanchez-Perez, et al.; Oncogene 16, 533 (1998) | (4) M.S. Razzaque, et al.; Histochem. Cell Biol. 111, 359 (1999) | (5) K. Seki, et al.; Cancer Chemother. Pharmacol. 45, 199 (2000) | (6) J. Lokich; Cancer Invest. 19, 756 (2001) | (7) R.N. Bose; Mini Rev. Med. Chem. 2, 103 (2002) | (8) Z.H. Siddik; Oncogene 22, 7265 (2003) | (9) R.C. Todd & S.J. Lippard; Metallomics 1, 280 (2009) | (10) H. Han, et al.; Nature Cell Biol. 24, 74 (2022)