(∓)-Propranolol hydrochloride
| Code | Size | Price |
|---|
| CDX-P0483-G025 | 25 g | £108.00 |
Quantity:
| CDX-P0483-G100 | 100 g | £304.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term Storage: +20?C. Long Term Storage: +4?C
Documents
Further Information
Alternate Names/Synonyms:
(?)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride; DL-Propranolol hydrochloride; ICI 45520; NSC 91523
Appearance:
White powder.
CAS:
318-98-9
EClass:
32160000
Form (Short):
solid
GHS Symbol:
GHS07
Handling Advice:
Keep under inert gas. Very hygroscopic.
Hazards:
H302
InChi:
InChI=1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H
InChiKey:
ZMRUPTIKESYGQW-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 318-98-9. Formula: C16H21NO2 . HCl. Molecular Weight: 295.8. (?)-Propranolol hydrochloride is a beta-adrenergic receptor (beta-AR) antagonist (Kds = 6.91, 0.832, and 117.49 nM for human beta1-, beta2- and beta3-ARs, respectively). It also acts as a non-specific 5-HT1/5-HT2 serotonin receptor antagonist, reducing tranylcypromine/L-tryptophan-induced hyperactivity in rats. (?)-Propranolol hydrochloride is useful as an antihypertensive drug, cardiac depressant and also in the treatment of angina pectoris. It decreases the effect of stress and exercise on heart by reducing the rate of contraction and conduction of impulse. It is known to competitively block the action of catecholamines.
MDL:
MFCD00012558
Molecular Formula:
C16H21NO2 . HCl
Molecular Weight:
295.8
Package Type:
Vial
Precautions:
P264 - P270 - P301 + P312 + P330 - P501
Product Description:
(?)-Propranolol hydrochloride is a beta-adrenergic receptor (beta-AR) antagonist (Kds = 6.91, 0.832, and 117.49 nM for human beta1-, beta2- and beta3-ARs, respectively). It also acts as a non-specific 5-HT1/5-HT2 serotonin receptor antagonist, reducing tranylcypromine/L-tryptophan-induced hyperactivity in rats. (?)-Propranolol hydrochloride is useful as an antihypertensive drug, cardiac depressant and also in the treatment of angina pectoris. It decreases the effect of stress and exercise on heart by reducing the rate of contraction and conduction of impulse. It is known to competitively block the action of catecholamines.
Purity:
>99% (TLC)
Signal word:
Warning
SMILES:
OC(CNC(C)C)COC1=CC=CC2=CC=CC=C21.Cl
Solubility Chemicals:
Soluble in DMSO (15mg/ml), ethanol (10mg/ml) or water (20mg/ml). Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4?C.
References
(1) J.D. Fitzgerald & S.R. O'Donnell; Br. J. Pharmacol. 45, 207 (1972) | (2) B. Basil, et al.; Br. J. Pharmacol. 50, 323 (1974) | (3) D.W. Costain & A.R. Green; Br. J. Pharmacol. 64, 193 (1978) | (4) S.E. Litwin, et al.; Br. J. Pharmacol. 127, 1671 (1999) | (5) J.G. Baker; Br. J. Pharmacol. 144, 317 (2005) | (6) M.J. Wagner, et al.; J. Exp. Pharmacol. 10, 51 (2018)