Cystatin C Antibody / Cystatin 3

Western blot: 0.5-1ug/ml,ELISA (capture): 1-5ug/ml (mouse recombinant protein)

Optimal dilution of the Cystatin C antibody should be determined by the researcher.

Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide

Cystatin C or cystatin 3, a protein encoded by the CST3 gene, is mainly used as a biomarker of kidney function. Recently, it has been studied for its role in predicting new-onset or deteriorating cardiovascular disease. It also seems to play a role in brain disorders involving amyloid, such as Alzheimer's disease. In humans, all cells with a nucleus (cell core containing the DNA) produce cystatin C as a chain of 120 amino acids. It is found in virtually all tissues and body fluids. It is a potent inhibitor of lysosomal proteinases (enzymes from a special subunit of the cell that break down proteins) and probably one of the most important extracellular inhibitors of cysteine proteases (it prevents the breakdown of proteins outside the cell by a specific type of protein degrading enzymes). Cystatin C belongs to the type 2 cystatin gene family.

Antigen affinity purified

0.5mg/ml if reconstituted with 0.2ml sterile DI water

Mouse Cystatin C recombinant protein (amino acids A21-A140) was used as the immunogen for the Cystatin C antibody.

This Cystatin C antibody is available for research use only.

Secreted

Antigen affinity

Mouse

P21460