NOX4 Antibody / NADPH oxidase 4
| Code | Size | Price |
|---|
| NSJ-RQ4482-100ul | 100ul | £535.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Monoclonal
Antibody Clone: E-14
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store the NOX4 antibody at -200.
Documents
Further Information
Application Details :
Western blot: 1:500-1:2000,Immunohistochemisty (FFPE): 1:50-1:200,Immunofluorescence: 1:50-1:200
Application Note:
Optimal dilution of the NOX4 antibody should be determined by the researcher.
Description:
Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity. [UniProt]
Format :
Purified
Formulation :
Antibody in PBS with 0.02% sodium azide and 50% glycerol
Immunogen:
A synthetic peptide from human NOX4 was used as the immunogen for the NOX4 antibody.
Limitation:
This NOX4 antibody is available for research use only.
Localization:
Cytoplasm (ER membrane)
Purity:
Protein A affinity
Species Reactivity :
Human, Mouse, Rat
Uniprot #:
Q9NPH5