14-3-3 sigma Antibody

14-3-3 protein sigma, Epithelial cell marker protein 1, Stratifin, SFN, HME1

Western blot: 1-3 ug/ml

Provided assay concentrations are suggestions only, 14-3-3 sigma antibody titration may be required for optimal results.

14-3-3 proteins are regulators of a diverse group of signaling proteins, including kinases, phosphatases, and transmembrane receptors, and have roles in a wide range of physiological processes including transcription, intracellular signaling, cell cycle control and apoptosis. There are seven 14-3-3 proteins in most mammals: beta, gamma epsilon, zeta, eta, sigma and tau. 14-3-3 sigma, also called Stratifin, is a product of the SFN gene. It is a tumor suppressor gene inactivated via DNA methylation. Reduced or no expression of 14-3-3 sigma is seen in various carcinoma including skin, breast and prostate, suggesting that 14-3-3 gene silencing may be involved in tumor progression.

PBS with 0.1 mg/ml BSA and 0.05% sodium azide

0.5 mg/mL

Unconjugated

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

A recombinant protein fragment from the internal region of 14-3-3 sigma was used as the immunogen for this antibody. The amino acid sequence is common to the ~30kDa and ~20kDa isoforms.

2810

stratifin

SFN

Homo sapiens

Liquid

Protein A affinity chromatography

Neuroscience,Signal Transduction

P31947

Optimal dilutions for each application to be determined by the researcher