BRCA1 Antibody [BRCA1/1398]

Breast cancer type 1 susceptibility protein, 632-, RING finger protein 53, BRCA1, RNF53

Flow Cytometry: 2-4 ug/million cells in 0.1ml

Immunofluorescence: 2-4 ug/ml

IHC (FFPE): 5-10 ug/ml

Optimal dilution of the BRCA1 antibody should be determined by the researcher.

BRCA1 (Breast cancer type 1 susceptibility protein) is a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

PBS with 0.1 mg/ml BSA and 0.05% sodium azide

0.2 mg/mL

Unconjugated

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Amino acids 445-620 were used as the immunogen for the BRCA1 antibody.

672

breast cancer 1, early onset

BRCA1

Homo sapiens

Liquid

Protein G affinity chromatography

Cancer,Cell Cycle

P38398

Optimal dilutions for each application to be determined by the researcher