Cadherin 16 Antibody

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ProSci
Product Code: PSI-33-641
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-33-641-100ug100ug£765.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunofluorescence (IF)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
Shipping:
blue ice
Storage:
Aliquot and Store at -20C. Avoid freez-thaw cycles.

Images

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IHC testing of FFPE human renal cell carcinoma with Cadherin 16 antibody. Required HIER: steam sections in 10mM Tris with 1mM EDTA, pH 9, for 10-20 min.
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IHC testing of FFPE human renal cell carcinoma with Cadherin 16 antibody. Required HIER: steam sections in 10mM Tris with 1mM EDTA, pH 9, for 10-20 min.

Documents

Further Information

Additional Names:
Cadherin-16, Kidney-specific cadherin, Ksp-cadherin, CDH16
Application Note:
Flow Cytometry: 0.5-1ug/10e6 cells

Immunofluorescence: 1-2 ug/ml

Immunohistochemistry (FFPE): 0.5-1 ug/ml for 30 min at RT

Optimal dilution of the Cadherin 16 antibody to be determined by the researcher.
Background:
Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that CDH16 (kidney-specific cadherin, Cadherin 16) is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, CDH16 is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels. CDH16 has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.2 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
A recombinant human protein was used as the immunogen for the Cadherin 16 antibody.
NCBI Gene ID #:
1014
NCBI Official Name:
cadherin 16, KSP-cadherin
NCBI Official Symbol:
CDH16
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Purification:
Protein A affinity chromatography
Research Area:
Signal Transduction
Swissprot #:
O75309
User NOte:
Optimal dilutions for each application to be determined by the researcher