CD104 Antibody [346-11A]
| Code | Size | Price |
|---|
| PSI-99-003-0.5mg | 0.5mg | £642.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2a
Antibody Clonality: Monoclonal
Antibody Clone: [346-11A]
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Shipping:
blue ice
Storage:
Store vial at -20˚C
Documents
Further Information
Additional Names:
Integrin beta4
Application Note:
CD104 Antibody [346-11A] for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, and immunoprecipitation assays.
Background:
CD104 represents the integrin beta4 subunit that associates non-covalently with integrin alpha6 (CD49f) to form the alpha6beta4 integrin heterodimer. The alpha6beta4 complex is expressed on the basal surface of a variety of epithelial cell types particularly on stratified squamous epithelia. It is also found in peripheral nerves, in certain subsets of endothelial cells, and on immature thymocytes. It also has been found to be associated with a number of malignant tissues. Hemidesmosomal alpha6beta4 plays an important role in the adhesion of epithelial cells to basement membranes via interactions with laminin and/or kalinin anchoring filaments. It is not known if the monoclonal antibody 346-11A can block this adhesion.
Buffer:
Supplied in PBS
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Tumor-associated antigen TSP-180 purified from a transplantable BALB/c carcinoma
NCBI Gene ID #:
192897
NCBI Official Name:
integrin beta 4
NCBI Official Symbol:
Itgb4
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
A2A863
Research Area:
Signal Transduction
SPECIFICITY:
CD104
Swissprot #:
A2A863
User NOte:
Optimal dilutions for each application to be determined by the researcher.