CD105 Antibody [ENG/1327]
| Code | Size | Price |
|---|
| PSI-33-704-100ug | 100ug | £765.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: ENG/1327
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunofluorescence (IF)
- Western Blot (WB)
Shipping:
blue ice
Storage:
Aliquot and Store at -20C. Avoid freez-thaw cycles.
Documents
Further Information
Application Note:
Immunofluorescence: 1-2 ug/ml
WB: 1-2 ug/ml
Flow Cytometry: 0.5-1 ug/million cells in 0.1ml
Titering of the Endoglin antibody may be required for optimal performance.
WB: 1-2 ug/ml
Flow Cytometry: 0.5-1 ug/million cells in 0.1ml
Titering of the Endoglin antibody may be required for optimal performance.
Background:
CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. It is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.2 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
A partial recombinant protein corresponding to amino acids 74-251 of human CD105/Endoglin was used as the immunogen for the Endoglin antibody.
Physical State:
Liquid
Purification:
Protein G affinity chromatography
Research Area:
Immunology, Stem Cell, Cancer
User NOte:
Optimal dilutions for each application to be determined by the researcher