CD106 Antibody [M/K-2] (Biotin)

VCAM-1, INCAM-110

CD106 Antibody [M/K-2] for use in flow cytometry, immunohistochemistry, western blotting, and immunoprecipitation assays.

CD106, also known as VCAM-1, is an adhesion molecule and a major mediator of the inflammatory response. It is expressed on activated microvascular endothelial cells in response to signals arising from immune responses in infection, graft rejection, tumor recognition and killing. The complementary binding ligand for VCAM-1 is VLA-4/CD49d. In addition to VCAM-1, VLA-4 also recognizes the extracellular matrix molecule fibronectin. This pairing of VCAM-1 and VLA-4 is able to provide a second signal (e.g., non-antigen specific) for T cell stimulation, such as that seen in transplantation. The monoclonal antibody MK-2 has been used in transplant studies to suppress cardiac rejection and induce long-term cardiac graft survival. In addition to inflammatory responses, VCAM-1 has a significant role in hemopoiesis through its ability to retain lymphocyte and myeloid precursors on stromal cells in the marrow and lymphoid organs. CD106/VCAM-1 exists as an integral membrane protein. The M/K-2 monoclonal antibody immunoprecipitates a peptide that gives a single band on SDS-PAGE gels with an apparent Mr of ~100 kDa under reducing conditions and 92 kDa under non-reducing conditions.

Supplied in PBS/NaN3

0.5 mg/mL

Biotin

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

BALB/3T3 and +/+2.4 cells

22329

vascular cell adhesion molecule 1

Vcam1

Mus musculus

Liquid

P29533

Cancer,Signal Transduction,Neuroscience,Stem Cell

CD106

P29533

Optimal dilutions for each application to be determined by the researcher.